Abstract

Research Article

Acute kidney injury in Colombian patients with COVID-19 who received kidney support therapy with genius® 90 technology

Emilio Rey-Vela, Jesús Muñoz, Rodrigo Daza-Arnedo, Rodrigo Daza-Arnedo, Katherin Portela-Buelvas, Nehomar Pájaro-Galvis*, Víctor Leal-Martínez, Emilio Abuabara-Franco, José Cabrales-Juan, Leonardo Marín, Lucas Daza, Samuel Cuadro, Emir Ortiz, María Raad-Sarabia, Cesar Ferrer, Alejandra Prada, Greisy González, Elkin Mendoza, Klearly Tinoco, Jorge Camacho, Joel Ortega, Carlos Tobón, Juan Montes, Jorge Coronado, Luis Salgado-Montiel, José Correa, Fabio Salas, Amilkar Almanza-Hurtado and Miguel Aguilar-Schorborg

Published: 11 September, 2020 | Volume 4 - Issue 3 | Pages: 056-060

Introduction: Acute kidney injury (AKI) is one of the complications associated with severe COVID-19 infection, and it can present in up to 20% to 40% of the cases; of these, approximately 20% will require renal replacement therapy (RRT).

Objective: To establish clinical and laboratory characteristics in a group of patients from Colombia with COVID-19 infection and AKI that received intermittent and prolonged RRT with the GENIUS® 90 technology in between March and July 2020.

Design: Cross-sectional study.

Results: 78.9% of participants were men and 21.1% were women. The main comorbidities were the following: Hypertension (65.3%), diabetes mellitus (38.9%), obesity (26.3%), cancer (5.3%), Chronic obstructive pulmonary disease (11.6%), cardiovascular disease (23.2%), active smoking (11.6%). 33.7% had chronic kidney disease (CKD) in the average serum creatinine on admission was 4.4 mg/dl.

The following inflammatory markers were elevated: C-reactive protein (CRP), d-dimer and ferritin (20.3 mg/dl, 931mcg/l and 1174 ng/ml, respectively). 63.5% of patients underwent sustained low-efficiency dialysis (SLED) (6 to 12 hours) and the rest of the patients (36.35%) underwent conventional hemodialysis (less than 4 hours). The mortality of the total patient sample was 36.9%, lower in patients with CKD than in patients with no previous renal disease history (18.7% and 40.1%, respectively).

Conclusion: Renal complications are frequent in patients with severe COVID-19. The development of AKI could be an isolated prognostic marker associated with an increase in mortality in patients with COVID-19, and one of the options is intermittent and prolonged RRT with the GENIUS® 90 system.

Read Full Article HTML DOI: 10.29328/journal.jcn.1001059 Cite this Article Read Full Article PDF

Keywords:

Coronavirus; Acute kidney injury; Renal replacement therapy

References

  1. Yuki K, Fujiogi M, Koutsogiannaki S. COVID-19 pathophysiology: A review. Clin Immunol. 2020 215: 108427. https://linkinghub.elsevier.com/retrieve/pii/S152166162030262X
  2. Sinha P, Matthay MA, Calfee CS. Is a “Cytokine Storm” Relevant to COVID-19? JAMA Intern Med. 2020. https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2767939
  3. Ronco C, Reis T, Husain-Syed F. Management of acute kidney injury in patients with COVID-19. The Lancet Respiratory Medicine. 2020; 8: 738-742. Available at: https://linkinghub.elsevier.com/retrieve/pii/S2213260020302290
  4. Robba C, Battaglini D, Pelosi P, Rocco PRM. Multiple organ dysfunction in SARS-CoV-2: MODS-CoV-2. Expert Review of Respiratory Medicine. 2020; 1-4. https://www.tandfonline.com/doi/full/10.1080/17476348.2020.1778470
  5. Daza Arnedo R, Aroca Martínez G, Rico Fontalvo JE, Rey Vela E, Pájaro Galvis NE, et al. Terapias de purificación sanguínea en COVID-19. Rev Colomb Nefrol. 2020; 7: 33-34. https://revistanefrologia.org/index.php/rcn/article/view/476
  6. Ronco, C., Reis, T. Kidney involvement in COVID-19 and rationale for extracorporeal therapies. Nat Rev Nephrol. 2020; 16: 308–310.
  7. Benedetti, C., Waldman, M., Zaza, G., Riella, L. Cravedi, P. COVID-19 and the kidneys: An Update. Front. Med. 2020.
  8. Gonzalez C, Yama E, Yomayusa N, Vargas J, Rico J, et al. Consenso colombiano de expertos sobre recomendaciones informadas en la evidencia para la prevención, diagnóstico y manejo de la lesión renal aguda por SARS-CoV-2/COVID-19. Rev Colomb Nefrol 2020; 7(Supl2). https://revistanefrologia.org/index.php/rcn/article/view/473
  9. Chan L, Chaudhary K, Saha A, Chauhan K, Vaid A, et al. Acute Kidney Injury in Hospitalized Patients with COVID-19 [Internet]. Nephrology. 2020. http://medrxiv.org/lookup/doi/10.1101/2020.05.04.20090944
  10. Hirsch JS, Ng JH, Ross DW, Sharma P, Shah HH, et al. Acute kidney injury in patients hospitalized with COVID-19. Kidney International. 2020; 98: 209-218. https://linkinghub.elsevier.com/retrieve/pii/S0085253820305329
  11. Ng JJ, Luo Y, Phua K, Choong AMTL. Acute kidney injury in hospitalized patients with coronavirus disease 2019 (COVID-19): A meta-analysis. J Infect. 2020; S0163445320302802. https://linkinghub.elsevier.com/retrieve/pii/S0163445320302802
  12. Maria Dolores del Pino. REGISTRO FRACASO RENAL AGUDO COVID-19 Informe 1. Sociedad Española de Nefrología. 2020.: https://us10.campaign-archive.com/?u=758507e42a1311e40debf34ad&id=a177db805b
  13. Richardson S, Hirsch JS, Narasimhan M, Crawford JM, et al. Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area. JAMA. 2020; 323: 2052. https://jamanetwork.com/journals/jama/fullarticle/2765184
  14. Rubin S, Orieux A, Prevel R, Garric A, Bats ML, et al. Characterization of acute kidney injury in critically ill patients with severe coronavirus disease 2019. Clin Kidney J. 2020; sfaa099. https://academic.oup.com/ckj/advance-article/doi/10.1093/ckj/sfaa099/5854260
  15. Pahl MV, Vaziri ND. Immune Function in Chronic Kidney Disease. En: Chronic Renal Disease. Elsevier. 2015; 285-297. https://linkinghub.elsevier.com/retrieve/pii/B978012411602300024X
  16. Kato S, Chmielewski M, Honda H, Pecoits-Filho R, Matsuo S, et al. Aspects of Immune Dysfunction in End-stage Renal Disease. CJASN. 2020; 3: 1526-1533. http://cjasn.asnjournals.org/lookup/doi/10.2215/CJN.00950208
  17. Lamarche C, Iliuta IA, Kitzler T. Infectious Disease Risk in Dialysis Patients: A Transdisciplinary Approach. Can J Kidney Health Dis. 2020; 6: 205435811983908. http://journals.sagepub.com/doi/10.1177/2054358119839080
  18. Ronco C, Reis T. Kidney involvement in COVID-19 and rationale for extracorporeal therapies. Nat Rev Nephrol. 2020; 16: 308–310.
  19. Benedetti C, Waldman M, Zaza G, Riella L, Cravedi, P. COVID-19 and the kidneys: An Update. Front Med. 2020.

Similar Articles

  • Acute Tubulointerstitial Nephritis due to Phenytoin: Case Report
    Nilzete Liberato Bresolin*, Pedro Docusse Junior, Maria Beatriz Cacese Shiozawa, Marina Ratier de Brito Moreira and Natalia Galbiatti Silveira Nilzete Liberato Bresolin*,Pedro Docusse Junior,Maria Beatriz Cacese Shiozawa,Marina Ratier de Brito Moreira,Natalia Galbiatti Silveira. Acute Tubulointerstitial Nephritis due to Phenytoin: Case Report. . 2017 doi: 10.29328/journal.jcn.1001004; 1: 019-025
  • The outcome of Acute Kidney Injury in patients with severe Malaria
    João Egidio Romão Jr* and João Alberto Brandão João Egidio Romão Jr*,João Alberto Brandão. The outcome of Acute Kidney Injury in patients with severe Malaria. . 2017 doi: 10.29328/journal.jcn.1001007; 1: 048-054
  • AngioJetTM rheolytic thrombectomy induced intravascular haemolysis leading to Acute Kidney Injury requiring Dialysis
    Hultin Sebastian*, Murali Karumathil and Nguyen Tam Hultin Sebastian*,Murali Karumathil,Nguyen Tam. AngioJetTM rheolytic thrombectomy induced intravascular haemolysis leading to Acute Kidney Injury requiring Dialysis. . 2018 doi: 10.29328/journal.jcn.1001015; 2: 025-028
  • Challenges of haemodialysis: A single centre experience in South West Nigeria
    Samuel Ayokunle Dada*, Adebukola Bidemi Ajite, Funmilayo Abimbola Ibitoba, Awolowo Anthony Thomas, Oluwamayowa Esther Dada and Olabisi Olamide Deji-Dada Samuel Ayokunle Dada*,Adebukola Bidemi Ajite,Funmilayo Abimbola Ibitoba,Awolowo Anthony Thomas,Oluwamayowa Esther Dada,Olabisi Olamide Deji-Dada. Challenges of haemodialysis: A single centre experience in South West Nigeria . . 2019 doi: 10.29328/journal.jcn.1001026; 3: 055-060
  • Urinary NGAL incorporation into Renal Angina Index for early detection of acute kidney injury in critically ill children
    Ali Mohammed Abu Zeid, Doaa Youssef Mohammed*, Amal Saeed AbdAlazeem, Anas Saad Elsayed mohammed Seddeeq and Ashraf Mohamed Elnaany Ali Mohammed Abu Zeid,Doaa Youssef Mohammed*,Amal Saeed AbdAlazeem,Anas Saad Elsayed mohammed Seddeeq,Ashraf Mohamed Elnaany. Urinary NGAL incorporation into Renal Angina Index for early detection of acute kidney injury in critically ill children. . 2019 doi: 10.29328/journal.jcn.1001032; 3: 093-099
  • Granulomatosis with polyangiitis (GPA) in a 76-year old woman presenting with pulmonary nodule and accelerating acute kidney injury
    Noor Sameh Darwich*, Melissa Schnell and L. Nicholas Cossey Noor Sameh Darwich*,Melissa Schnell,L. Nicholas Cossey. Granulomatosis with polyangiitis (GPA) in a 76-year old woman presenting with pulmonary nodule and accelerating acute kidney injury. . 2020 doi: 10.29328/journal.jcn.1001048; 4: 001-006
  • Biomarkers in acute kidney injury
    Nehomar Pajaro Galvis*, Jorge Rico-Fontalvo, Rodrigo Daza-Arnedo, Maria Ximena Cardona-Blanco, Emilio Abuabara-Franco, Victor Leal-Martínez, Jose Cabrales-Juan, José Correa-Guerrero, José Bohórquez-Rivero, José Sáenz-López, José Restom-Arrieta, Milton Rivera-Moreno, Estefany Rivera-Moreno, Maria Monterrosa-Robles, Alonso Pomares-Lara, Dayana Ayola-Rosales and Ana Alonso-Henriquez Nehomar Pajaro Galvis*,Jorge Rico-Fontalvo,Rodrigo Daza-Arnedo,Maria Ximena Cardona-Blanco,Emilio Abuabara-Franco,Victor Leal-Martínez,Jose Cabrales-Juan,José Correa-Guerrero,José Bohórquez-Rivero,José Sáenz-López,José Restom-Arrieta,Milton Rivera-Moreno,Estefany Rivera-Moreno,Maria Monterrosa-Robles,Alonso Pomares-Lara,Dayana Ayola-Rosales,Ana Alonso-Henriquez. Biomarkers in acute kidney injury. . 2020 doi: 10.29328/journal.jcn.1001056; 4: 027-035
  • Acute kidney injury in Colombian patients with COVID-19 who received kidney support therapy with genius® 90 technology
    Emilio Rey-Vela, Jesús Muñoz, Rodrigo Daza-Arnedo, Rodrigo Daza-Arnedo, Katherin Portela-Buelvas, Nehomar Pájaro-Galvis*, Víctor Leal-Martínez, Emilio Abuabara-Franco, José Cabrales-Juan, Leonardo Marín, Lucas Daza, Samuel Cuadro, Emir Ortiz, María Raad-Sarabia, Cesar Ferrer, Alejandra Prada, Greisy González, Elkin Mendoza, Klearly Tinoco, Jorge Camacho, Joel Ortega, Carlos Tobón, Juan Montes, Jorge Coronado, Luis Salgado-Montiel, José Correa, Fabio Salas, Amilkar Almanza-Hurtado and Miguel Aguilar-Schorborg Emilio Rey-Vela,Jesús Muñoz,Rodrigo Daza-Arnedo,Rodrigo Daza-Arnedo,Katherin Portela-Buelvas,Nehomar Pájaro-Galvis*,Víctor Leal-Martínez,Emilio Abuabara-Franco,José Cabrales-Juan,Leonardo Marín,Lucas Daza,Samuel Cuadro,Emir Ortiz,María Raad-Sarabia,Cesar Ferrer,Alejandra Prada,Greisy González,Elkin Mendoza,Klearly Tinoco,Jorge Camacho,Joel Ortega,Carlos Tobón,Juan Montes,Jorge Coronado,Luis Salgado-Montiel,José Correa,Fabio Salas,Amilkar Almanza-Hurtado,Miguel Aguilar-Schorborg. Acute kidney injury in Colombian patients with COVID-19 who received kidney support therapy with genius® 90 technology. . 2020 doi: 10.29328/journal.jcn.1001059; 4: 056-060
  • COVID-19 related rhabdomyolysis
    Alejandro Munoz-Martinez, Maham Akbar Waheed, Kenar D Jhaveri and Geurys Rojas-Marte* Alejandro Munoz-Martinez,Maham Akbar Waheed,Kenar D Jhaveri,Geurys Rojas-Marte*. COVID-19 related rhabdomyolysis. . 2020 doi: 10.29328/journal.jcn.1001061; 4: 065-069
  • Modification of the Renal Angina Index for identifying the need for renal replacement therapy in critically ill pediatric patients
    Erin K Stenson*, John T Brinton, Liz Beil, Danielle E Soranno and Katja M Gist Erin K Stenson*,John T Brinton,Liz Beil,Danielle E Soranno,Katja M Gist. Modification of the Renal Angina Index for identifying the need for renal replacement therapy in critically ill pediatric patients. . 2020 doi: 10.29328/journal.jcn.1001062; 4: 070-076

Recently Viewed

Read More

Most Viewed

Read More

Help ?