Abstract

Research Article

Elimination of Medium/High Molecular Weight Solutes. Comparison of High Flow Hemodialysis with Extended Hemodialysis

Manuel Benítez Sánchez*, Sergio Barrero, Maria R Da Silva, Carlos Martinez, Guillermo Manuel Tirado and Sonia Cruz

Published: 13 May, 2024 | Volume 8 - Issue 2 | Pages: 066-075

Introduction: Post-dilution online hemodiafiltration is the most efficient extracorporeal depurative treatment of CKD. Recently a new type of membrane has been developed, with a higher cut-off point also called a medium cut-off point, which has the capacity to eliminate higher molecular weight molecules in hemodialysis. The hemodialysis performed with these membranes has been called “Expanded Hemodialysis”.
Objective: Compare the purifying efficacy of medium and high molecular weight molecules in patients dialyzed with high-flux hemodialysis, VitaPES 210HF, and with patients treated with expanded hemodialysis with the medium cut-off dialyzer, Elisio-HX.
We also assessed the effect that the increased removal of inflammatory mediators by MCO hemodialysis had on fecal Calprotectin levels.
Patients and methods: This is a prospective observational cross-over study in which 8 prevalent hemodialysis patients were followed for two months. Blood levels of IL-6, C-reactive protein (CRP), β2-microglobulin, Kappa and Lambda immunoglobulin light chains, and serum albumin were determined before and after each hemodialysis session.
Results: The percentage of reduction of medium and higher molecular weight molecules: β2microglobulin, IL-6, Kappa and Lambda chains and CRP were higher with the Elisio-21HX dialyzer compared to the VitaPES 210HF dialyzer. There was no difference in albumin clearance between the two dialyzers.
Fecal calprotectin levels were lower in patients dialyzed with Elisio-21HX.
Conclusion: The medium cutoff dialyzer, Elisio-HX, is more efficient in the elimination of medium/high molecular weight molecules than the VitaPES HF high-flux dialyzer, with the same albumin elimination.
Improving inflammation at the local intestinal level with lower levels of fecal Calprotectin.

Read Full Article HTML DOI: 10.29328/journal.jcn.1001129 Cite this Article Read Full Article PDF

Keywords:

Extended hemodialysis; Depurative efficacy; Reduction ratio; β2 Microglobulin; IL-6; Inflammation; Calprotectin

References

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