Abstract

Research Article

Anatomo-clinical and Etiological Profile of Nephropathies Biopsied in the Nephrology Department of the Thies Regional Hospital (Senegal)

Ameth Dieng*, Modou Ndongo, Rokhaya Fall, Mame Selly Diawara and Mouhamadou Moustapha Cissé

Published: 30 September, 2024 | Volume 8 - Issue 3 | Pages: 127-131

Introduction: In many developing countries, particularly in Africa, the use of renal biopsy (RB) in clinical nephrology is severely lacking. The objectives were to describe the anatomoclinical and etiological profile of these biopsied nephropathies, as well as the factors associated with the etiology of the nephropathies.
Patients and method: This was a retrospective descriptive and analytical study from 1 April 2020 to 30 October 2022. The patients were selected from the renal biopsy register of the nephrology department of the Thiès Regional Hospital. Sociodemographic, clinical, biological, and histological parameters were studied.
Results: 75 renal biopsies were included. The mean age was 33.3 ± 14.8 years, with a male predominance (65.3%). The main indications were nephrotic syndrome in 50.67% of cases. RB was adequate in 82.7%, inadequate in 13.3%, and borderline in 4%. Glomerular nephropathies predominated, with focal segmental glomerulosclerosis (FSGS) in 34.7%, membranous nephropathy (MN) in 17.3%, minimal change disease (MCD) in 10.67%, extracapillary glomerulonephritis (ECGN) in 5.3% and lupus nephritis (LN) in 3.9%. Thrombotic microangiopathy (TMA) was found in 9.3%. Chronic tubulointerstitial nephropathy (CTIN) accounted for 5.3% of all RB and acute tubular necrosis (ATN) for 4%. The etiologies were primary in 48%, secondary in 28%, and undetermined in 24%. In the bivariate analysis, the etiology was correlated with the mean SBP (p = 0.023), the mean level of hemoglobin (p = 0.028), the levels of GFR (p = 0.017), and the type of kidney disease (p = 0.000).
Conclusion: Glomerular nephropathy was more frequent and FSGS was the most common histological lesion found. Primary causes predominated. Associated factors were identified to improve patient management.

Read Full Article HTML DOI: 10.29328/journal.jcn.1001140 Cite this Article Read Full Article PDF

Keywords:

Biopsy; Renal; Nephropathy; Etiology

References

  1. Maisonneuve P, Agodoa L, Gellert R, Stewart JH, Buccianti G, Lowenfels AB, et al. Distribution of primary renal diseases leading to end-stage renal failure in the United States, Europe, and Australia/New Zealand: results from an international comparative study. Am J Kidney Dis. 2000;35(1):157-65. Available from: https://doi.org/10.1016/s0272-6386(00)70316-7
  2. Iversen P, Brun C. Aspiration biopsy of the kidney. Am J Med. 1951;11(3):324-330. Available from: https://doi.org/10.1016/0002-9343(51)90169-6
  3. Okpechi IG, Swanepoel CR, Duffield M, Mahala B, Wearne N, Alagbe S, et al. Patterns of renal disease in Cape Town, South Africa. Nephrol Dial Transplant. 2011;26(6):1853-1861. Available from: https://doi.org/10.1093/ndt/gfq655
  4. Lemrabott AT, Dial MC, Faye M, Cissé MM, Samb A, Seck SM, et al. Senegalese renal biopsy registry: descriptive analysis of 492 nephropathies biopsied from 2009 to 2012. Nephrology & Therapeutics. 2016;12(5):269. Available from: https://doi.org/10.1016/j.nephro.2016.07.339
  5. Zerdoumi F, Medjamia M, Boudani S. Epidemiological profile of nephropathy. Therapeutic Nephrology. 2021;17(5):318-329. Available from: https://doi.org/10.1016/j.nephro.2021.07.185
  6. Mbarki H, Belghiti KA, Harmouch T, Najdi A, Arrayhani M, Sqalli T. Kidney biopsy puncture in the Nephrology Department of Fez: indications and results: about 522 cases. Pan Afr Med J. 2016;24:21. Available from: https://doi.org/10.11604%2Fpamj.2016.24.21.3982
  7. Mhamedi SA, Meghraoui H, Benabdelhak M, Bentata Y, Haddiya I. Renal biopsy: indications, complications and results. Pan Afr Med J. 2018;31:44. Available from: https://doi.org/10.11604/pamj.2018.31.44.15604
  8. Kallossy Ousmane. Renal biopsy: indications, results and complications in the nephrology and hemodialysis department of the Luxembourg mother-child hospital [exercise thesis]. Mali: University of Sciences, Techniques and Technologies of Bamako; 2021.
  9. Diouf B, Ka EF, Niang A, Mbengue M, Ka MM, Diouf ML, et al. Analysis of 115 kidney biopsies performed in Dakar (Senegal). Dakar Med. 2001;46(1):51-53. Available from: https://pubmed.ncbi.nlm.nih.gov/15773158/
  10. Lemrabott AT, Faye M, Cissé MM, Fall K, Seck SM, Kane Y, et al. Senegalese kidney biopsy registry: descriptive analysis of 1559 nephropathies biopsied over a period of 7 years. Therapeutic Nephrology. 2019;15(5):273-283. Available from: https://doi.org/10.1016/j.nephro.2019.07.029
  11. Keita Y, Dial CMM, Sylla A, Lemrabott AT, Faye M, Cissé MM, et al. Pathological profile of primary segmental and focal hyalinosis (HSF) in children in Dakar: about 61 cases. Therapeutic Nephrology. 2016;12(5):341-350. Available from: https://doi.org/10.1016/j.nephro.2016.07.157
  12. Eljouehari M, Flayou K, Raoundi O, Benamar L, Rhou H, Bayahia R, et al. Pathological and evolutionary profile of primary idiopathic segmental and focal hyalinosis. Therapeutic Nephrology. 2015;11(5):379-388. Available from: https://doi.org/10.1016/j.nephro.2015.07.352
  13. Nyirahabineza A. Idiopathic segmental and focal hyalinosis: About 104 cases [Exercise thesis]. Morocco: Mohammed V University of Rabat; 2016.
  14. D’Agati VD, Alster JM, Jennette JC, Thomas DB, Pullman J, Savino DA, et al. Association of histologic variants in FSGS clinical trial with presenting features and outcomes. Clin J Am Soc Nephrol. 2013;8(3):399-406. Available from: https://doi.org/10.2215/cjn.06100612
  15. Traore H, Maiza H, Emal V, Dueymes JM. Renal biopsy: indications, complications and results in 243 renal biopsies. Nephrology & Therapeutics. 2015;11(5):339-348. Available from: https://doi.org/10.1016/j.nephro.2015.07.249
  16. Covic A, Schiller A, Volovat C, Gluhovschi G, Gusbeth-Tatomir P, Petrica L, et al. Epidemiology of renal disease in Romania: a 10 year review of two regional renal biopsy databases. Nephrol Dial Transplant. 2006;21(2):419-424. Available from: https://doi.org/10.1093/ndt/gfi207

Figures:

Similar Articles

Recently Viewed

  • Synthesis of Carbon Nano Fiber from Organic Waste and Activation of its Surface Area
    Himanshu Narayan*, Brijesh Gaud, Amrita Singh and Sandesh Jaybhaye Himanshu Narayan*,Brijesh Gaud,Amrita Singh,Sandesh Jaybhaye. Synthesis of Carbon Nano Fiber from Organic Waste and Activation of its Surface Area. Int J Phys Res Appl. 2019: doi: 10.29328/journal.ijpra.1001017; 2: 056-059
  • Obesity Surgery in Spain
    Aniceto Baltasar* Aniceto Baltasar*. Obesity Surgery in Spain. New Insights Obes Gene Beyond. 2020: doi: 10.29328/journal.niogb.1001013; 4: 013-021
  • Tamsulosin and Dementia in old age: Is there any relationship?
    Irami Araújo-Filho*, Rebecca Renata Lapenda do Monte, Karina de Andrade Vidal Costa and Amália Cinthia Meneses Rêgo Irami Araújo-Filho*,Rebecca Renata Lapenda do Monte,Karina de Andrade Vidal Costa,Amália Cinthia Meneses Rêgo. Tamsulosin and Dementia in old age: Is there any relationship?. J Neurosci Neurol Disord. 2019: doi: 10.29328/journal.jnnd.1001025; 3: 145-147
  • Case Report: Intussusception in an Infant with Respiratory Syncytial Virus (RSV) Infection and Post-Operative Wound Dehiscence
    Lamin Makalo*, Orlianys Ruiz Perez, Benjamin Martin, Cherno S Jallow, Momodou Lamin Jobarteh, Alagie Baldeh, Abdul Malik Fye, Fatoumatta Jitteh and Isatou Bah Lamin Makalo*,Orlianys Ruiz Perez,Benjamin Martin,Cherno S Jallow,Momodou Lamin Jobarteh,Alagie Baldeh,Abdul Malik Fye,Fatoumatta Jitteh,Isatou Bah. Case Report: Intussusception in an Infant with Respiratory Syncytial Virus (RSV) Infection and Post-Operative Wound Dehiscence. J Community Med Health Solut. 2025: doi: 10.29328/journal.jcmhs.1001051; 6: 001-004
  • The prevalence and risk factors of chronic kidney disease among type 2 diabetes mellitus follow-up patients at Debre Berhan Referral Hospital, Central Ethiopia
    Getaneh Baye Mulu, Worku Misganew Kebede, Fetene Nigussie Tarekegn, Abayneh Shewangzaw Engida, Migbaru Endawoke Tiruye, Mulat Mossie Menalu, Yalew Mossie, Wubshet Teshome and Bantalem Tilaye Atinafu* Getaneh Baye Mulu,Worku Misganew Kebede,Fetene Nigussie Tarekegn,Abayneh Shewangzaw Engida,Migbaru Endawoke Tiruye,Mulat Mossie Menalu,Yalew Mossie,Wubshet Teshome,Bantalem Tilaye Atinafu*. The prevalence and risk factors of chronic kidney disease among type 2 diabetes mellitus follow-up patients at Debre Berhan Referral Hospital, Central Ethiopia. J Clini Nephrol. 2023: doi: 10.29328/journal.jcn.1001104; 7: 025-031

Read More

Most Viewed

Read More

Help ?