Published: 21 August, 2020 | Volume 4 - Issue 2 | Pages: 044-055
Figure 2:
Diabetic nephron. The increase in reabsorption of glucose by SGLT2 in the proximal convoluted tubule decreases the delivery of solutes to the macular density. The resulting decrease in ATP release from the basolateral membrane of the epithelial tubular cells reduces the production of adenosine produces vasodilatation of the afferent arteriole, leading to hyperfiltration and an increase in the glomerular capillary pressure. The increase infiltrate glucose produces inflammation and oxidative stress. Finally, the increase in oxygen consumption of the renal cortex can contribute to renal fibrosis by inducing hypoxia and differentiation of EPO producing fibroblasts in pro-fibrotic myofibroblasts (adapted from references 3 and 5).
Read Full Article HTML DOI: 10.29328/journal.jcn.1001058 Cite this Article Read Full Article PDF
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