Figure 2

SGLT2 Inhibitors and nephroprotection in diabetic kidney disease: From mechanisms of action to the latest evidence in the literature

Jorge Rico-Fontalvo, Rodrigo Daza-Arnedo, Maria Ximena Cardona-Blanco, Victor Leal-Martínez, Emilio Abuabara-Franco, Nehomar Pajaro-Galvis*, Jose Cabrales, José Correa, Manuel Cueto, Amable Duran, Alejandro Castellanos, Javier Enamorado, José Bohórquez, Isabella Uparella, Julio Zuñiga, Abraham Chagui, Alfonso Ramos and Luis Lara

Published: 21 August, 2020 | Volume 4 - Issue 2 | Pages: 044-055

jcn-aid1058-g002

Figure 2:

Diabetic nephron. The increase in reabsorption of glucose by SGLT2 in the proximal convoluted tubule decreases the delivery of solutes to the macular density. The resulting decrease in ATP release from the basolateral membrane of the epithelial tubular cells reduces the production of adenosine produces vasodilatation of the afferent arteriole, leading to hyperfiltration and an increase in the glomerular capillary pressure. The increase infiltrate glucose produces inflammation and oxidative stress. Finally, the increase in oxygen consumption of the renal cortex can contribute to renal fibrosis by inducing hypoxia and differentiation of EPO producing fibroblasts in pro-fibrotic myofibroblasts (adapted from references 3 and 5).

Read Full Article HTML DOI: 10.29328/journal.jcn.1001058 Cite this Article Read Full Article PDF

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