Figure 5

Collecting duct PGE2 responses reduce water loss with empagliflozin in mice with type 2 diabetes mellitus

R Nasrallah, J Zimpelmann, V Cheff, JF Thibodeau, KD Burns and RL Hébert*

Published: 08 April, 2021 | Volume 5 - Issue 1 | Pages: 023-030

jcn-aid1069-g005

Figure 5:

Renal EP receptor gene expression. RNA was isolated from microdissected proximal tubules (A, E, I), thick ascending limb (B, F), cortical (C+G) and inner medullary (D, H, J) collecting duct from 4 mouse groups: control (db/m), db/m+EMPA, diabetic db/db, and db/db+EMPA. Expression of EP1 (A-D), EP3 (E-H), and EP4 (I+J) receptor mRNA were measured by qPCR. Data was normalized to 18S and is presented as fold db/m of mean +/- SEM. * p < 0.05 vs. db/m, n = 3-6.

Read Full Article HTML DOI: 10.29328/journal.jcn.1001069 Cite this Article Read Full Article PDF

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