Figure 6

Collecting duct PGE2 responses reduce water loss with empagliflozin in mice with type 2 diabetes mellitus

R Nasrallah, J Zimpelmann, V Cheff, JF Thibodeau, KD Burns and RL Hébert*

Published: 08 April, 2021 | Volume 5 - Issue 1 | Pages: 023-030

jcn-aid1069-g006

Figure 6:

Renal sodium transporters gene expression. RNA was isolated from the renal cortex (A-C), and from microdissected proximal tubules (D+E) and thick ascending limb (F) from 4 mouse groups: control (db/m), db/m+EMPA, diabetic db/db, and db/db+EMPA. Expression of sodium-hydrogen exchanger (NHE)-3, epithelial sodium channel (ENaC), sodium-potassium-ATPase (NaK-ATPase), sodium glucose cotransporter (SGLT)-1 and SGLT-2, and sodium-potassium-2-chloride cotransporter (NKCC2) were measured by qPCR. Data was normalized to 18S and is presented as fold db/m of mean +/- SEM. *p < 0.05 vs. db/m, and black line indicates significance between two groups, n = 3-6.

Read Full Article HTML DOI: 10.29328/journal.jcn.1001069 Cite this Article Read Full Article PDF

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