Figure 4

An update on the approaches of avoidance of propagation of chronic kidney disease resulting in reversal or possible need or avoidance of kidney transplantation - a systematic review

Kulvinder Kochar Kaur*, Gautam Allahbadia and Mandeep Singh

Published: 10 May, 2022 | Volume 6 - Issue 2 | Pages: 040-057

jcn-aid1089-g004

Figure 4:

Courtesy ref no-6-The structure of various mineralocorticoids (MRAs). Antagonists of mineralocorticoids receptor like spironolactone possess the capacity of reduction of proteinuria as well as BP however are restrictive for CKD treatment in view of correlaton with reduction in GFR as well as hyperkalaemia [83-85]. Innovative nonsteroidal MRAs like esaxerenone along with finerenone got produced, possessing the greater capacity of antifibrotic along with antiinflammatory actions(In contrast to steroidal MRAs esaxerenone alongwith finerenone illustrated akin proteinuria reducing actions in patients with CKD along with lesser incidence of hyperkalaemia [88-90]. Furthermore, combination of Single blockade of RAAS with nonsteroidal MRAs demonstrated an akin AKI taking place with finerenone, however it gradually showed reduction in GFR in case of trials with esaxerenone MRAs generations such as spironolactone, eplerenone, and novel nonsteroidal MRAs (esaxerenone and finerenone). Novel nonsteroidal MRAs exert better anti-fibrotic and anti-inflammatory effects with renal tubular sparing effects on hyperkalemia. For details see Figure 4 along with text for details.

Read Full Article HTML DOI: 10.29328/journal.jcn.1001089 Cite this Article Read Full Article PDF

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